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Knee pain and symptoms, such as localized aching, sharp discomfort, swelling, stiffness, or instability, often signal underlying injuries (e.g., ligament tears, fractures) or conditions (e.g., arthritis, tendinitis). Pain may worsen with activity, weight-bearing, or prolonged sitting. Acute pain from trauma is sudden and severe, while chronic pain (e.g., osteoarthritis) persists, affecting mobility and quality of life. Management includes RICE (rest, ice, compression, elevation), over-the-counter analgesics (NSAIDs), and activity modification. Physical therapy strengthens muscles, improves flexibility, and corrects biomechanics. For chronic cases, corticosteroid injections, hyaluronic acid, or nerve blocks may provide relief. Advanced therapies like regenerative medicine (PRP, stem cells) or surgery address persistent issues. Red flags (fever, severe swelling, inability to bear weight) require urgent evaluation to rule out infections or structural damage. Personalized plans balance symptom control with addressing root causes to restore function.